Results 211 to 220 of about 417,611 (276)

SiCmiR Atlas: Single‐Cell miRNA Landscape Reveals Hub‐miRNA and Network Signatures in Human Cancers

Advanced Science, EarlyView.
SiCmiR predicts mature miRNA activity at single‐cell resolution using only 977 landmark genes, enabling scalable reconstruction of miRNA landscapes across diverse tissues and disease contexts. The SiCmiR Atlas integrates 9.36 million cells with analytical tools for hub‐miRNA discovery, biomarker prioritization, and regulatory network interrogation ...
Xiao‐Xuan Cai, Jing‐Shan Liao, Jia‐Jun Ma, Yu‐Xuan Pang, Yi‐Gang Chen, Yang‐Chi‐Dung Lin, Yi‐Dan Chen, Xin Cao, Yi‐Cheng Zhang, Tao‐Sheng Xu, Tzong‐Yi Lee, Hsi‐Yuan Huang, Hsien‐Da Huang   +12 more
wiley   +1 more source

Intraspecific variation for heat stress tolerance in wild emmer-derived durum wheat populations. [PDF]

Front Plant Sci
Balla MY, Kamal NM, Tahir ISA, Gorafi YSA, Abdalla MGA, Tsujimoto H.   +5 more
europepmc   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Effectiveness of written emotional disclosure interventions for eating disorders: a systematic review and meta-analysis. [PDF]

Front Nutr
Wang Y, Xu T, Tao Y, Cai X.
europepmc   +1 more source

Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD

Advanced Science, EarlyView.
Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du, Yinming Li, Rong Wu, Yufei Shen, Jiayi Yang, Xuan Xiao, Yu Zhou   +6 more
wiley   +1 more source

Development and validation of a kinematic hindlimb cycling model for rats. [PDF]

Sci Rep
Sweatland HM, Pettit E, Patel H, de la Mata N, Conover CF, Griffis EJ, Yarrow JF, Schiefer MA, Dixon WE.   +8 more
europepmc   +1 more source

Meta‐GWAS of Pig Semen Quality Traits Reveals Conserved Genes Regulating Mammalian Fertility

Advanced Science, EarlyView.
This study incorporated 14 210 individuals to perform a GWAS meta‐analysis of six semen quality traits. The GWAS meta‐analysis identifies 234 GWAS loci associated with semen quality traits. The incorporation with a functional genomics resource explains potential genetic regulation of ∼40% GWAS signals underlying semen quality traits.
Qing Lin, Xiaodian Cai, Zhanming Zhong, Tingting Li, Xinyou Chen, Wondossen Ayalew, Zhiting Xu, Chen Wei, Xiaoke Zhang, Hong Cheng, Zhenyang Zhang, Xuehua Li, Yongjie Tang, Siqian Chen, Jun Zhou, Jinglei Si, Xibo Wu, Chao Ning, Qishan Wang, Yuchun Pan, Yahui Gao, Jiaqi Li, Ying Yu, Zhe Zhang, Yunxiang Zhao, Lingzhao Fang, Zhe Zhang   +26 more
wiley   +1 more source

Structure of Weekly and Daily Physical Activity of Adults with Moderate and Severe Intellectual Disabilities in the Context of Barriers in Accessibility: A Preliminary Study. [PDF]

Brain Sci
Celebańska D, Rosołek B, Szreniawa B, Zwierzchowska A.   +3 more
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

The value of prognostic immune-inflammatory-nutritional score in predicting survival after surgery in stage I-III non-small cell lung cancer. [PDF]

J Thorac Dis
Gu Y, Zheng H, Wang J, Li X, Liu Y, Hu B.   +5 more
europepmc   +1 more source