Results 231 to 240 of about 417,611 (276)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

A Telemedicine System Using the Remote Diagnostic Imaging App "Join" for Emergency Medicine Throughout Wakayama Prefecture in Japan. [PDF]

Cureus
Fujita K, Takao H, Kato S, Nakao N, Ueno M, Nojiri T.   +5 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Pain Perceptions and Attitudes of Parents of Pediatric Age Group Patients Attending Emergency Departments in Saudi Arabia. [PDF]

Cureus
Hammad AA, Jamal Aldeen RI, Alzahrani AA, Alshareef IM, Alkhatabi TF, Ismail WM.   +5 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs. [PDF]

Imeta
Liu L, Yi G, Yao Y, Liu Y, Li J, Yang Y, Liu M, Fang L, Mo D, Zhang L, Liu Y, Niu Y, Wang L, Qu X, Pan Z, Wang L, Chen M, Fan X, Chen Y, Zhang Y, Li X, Wang Z, Tang Y, Huang H, Yuan P, Liao Y, Li X, Yin Z, Liu D, Zhang D, Zhou Q, Wu W, Jiang J, Gao Y, Liu GE, Wang L, Chen Y, Li K, Groenen MAM, Tang Z.   +39 more
europepmc   +1 more source

Directed evolution expands CRISPR-Cas12a genome-editing capacity. [PDF]

Nucleic Acids Res
Ma E, Chen K, Shi H, Wasko KM, Esain-Garcia I, Trinidad MI, Zhou K, Ye J, Doudna JA.   +8 more
europepmc   +1 more source

Is it a hemangioma? A combined case report of soft tissue sarcomas mimicking infantile hemangioma. [PDF]

J Surg Case Rep
Almutairi S, AlWabel W, Aljadaan S, Alsabty N, Alshehri A, Alrobian F.   +5 more
europepmc   +1 more source

Increased Recall of Negative Memories Following Initial Methylphenidate Administration in a 6-Year-Old Boy With ADHD: A Case Report. [PDF]

Neuropsychopharmacol Rep
Xiang Q, Xu L, Feng Y, Ye A, Liu B, Tan Y.   +5 more
europepmc   +1 more source