Results 51 to 60 of about 417,611 (276)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Longitudinal Cognitive Trajectories in Older Adults with Restless Legs Syndrome or Willis–Ekbom Disease

Life
Background: Restless legs syndrome/Willis–Ekbom disease (RLS/WED) has occasionally but not consistently been associated with cognitive and most notably language and executive impairment.
Ioannis Liampas, Vasileios Siokas, Andreas Kyrozis, George Sakoutis, Mary Yannakoulia, Mary H. Kosmidis, Paraskevi Sakka, Nikolaos Scarmeas, Georgios M. Hadjigeorgiou, Efthimios Dardiotis   +9 more
doaj   +1 more source

Clinicopathological features, survival outcomes, and appropriate surgical approaches for stage I acinar and papillary predominant lung adenocarcinoma

Cancer Medicine, 2020
Background Whether prognosis differs between lung acinar predominant adenocarcinoma (ACN) and papillary predominant adenocarcinoma (PAP) patients remains controversial. Furthermore, the appropriate surgical plan for each subtype is undetermined.
Di Lu, Jianjun Yang, Xiguang Liu, Siyang Feng, Xiaoying Dong, Xiaoshun Shi, Jianxue Zhai, Shijie Mai, Jianjun Jiang, Zhizhi Wang, Hua Wu, Kaican Cai   +11 more
doaj   +1 more source

Supplementation of multi-enzymes alone or combined with inactivated Lactobacillus benefits growth performance and gut microbiota in broilers fed wheat diets

Frontiers in Microbiology, 2022
The effects of multi-enzymes mixture supplementation or combination with inactivated Lactobacillus on growth performance, intestinal barrier, and cecal microbiota were investigated in broilers at the age of 15–42 days fed a wheat-based diet.
Qingtao Gao, Yanchun Wang, Jiaheng Li, Jiaheng Li, Guosong Bai, Lei Liu, Ruqing Zhong, Teng Ma, Hongbin Pan, Hongfu Zhang   +9 more
doaj   +1 more source

A Shifting Landscape: A Decade of Change in American Attitudes about Same-Sex Marriage and LGBT Issues [PDF]

, 2014
This national survey of more than 4,500 Americans finds that support for allowing gay and lesbian people to legally wed has jumped 21 percentage points over the last decade, from 32 percent in 2003 to 53 percent in 2013, transforming the American ...
Daniel Cox, Juhem Navarro-Rivera, Robert P. Jones   +2 more
core  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluation of upper endoscopic findings in patients with restless legs syndrome and gastric complaints [PDF]

Arquivos de Neuro-Psiquiatria
Background: The effect of gastrointestinal system disorders on Restless Legs Syndrome/Willis-Ekbom disease (RLS/WED) has been previously demonstrated by using serological tests.
Mustafa ÇAM, Ufuk KUTLUANA
doaj   +2 more sources

Estimation of mesospheric gravity wave momentum flux using Hybrid Doppler Interferometry [PDF]

, 2017
15th MST Radar WorkshopSession M6: Middle atmosphere dynamics and structureMay 31 (Wed), NIPR ...

core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source