Results 61 to 70 of about 417,611 (276)

Dynamic splinting in wrist extension following distal radius fractures

Journal of Orthopaedic Surgery and Research, 2010
Background Wrist flexion contracture is a common pathology which presents secondary to distal radius fractures. Joint stability, restoration and early mobilization are frequently achieved through surgical treatment after such an injury.
Willis F Buck, Berner Stacey H
doaj   +1 more source

Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage.

PLoS Biology, 2023
Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the Lb2Cas12a+crRNA complex, as well as the
Li Jianwei, Chacko Jobichen, Satoru Machida, Sun Meng, Randy J Read, Chen Hongying, Shi Jian, Yuren Adam Yuan, J Sivaraman   +8 more
doaj   +1 more source

Gravity wave measurements using spaced antenna and meteor radar techniques: A review [PDF]

, 2017
15th MST Radar WorkshopSession M6: Middle atmosphere dynamics and structureMay 31 (Wed), NIPR ...

core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Economic rationales for kin marriage: Assessing the evidence using Egyptian panel data

Demographic Research, 2019
Background: Although kin marriage is widely practiced in the Middle East, its underlying motivations have not been thoroughly tested. Methods: We assess evidence for two economic rationales motivating kin unions using a national sample of Egyptians ...
Rania Salem, Sarah Shah
doaj   +1 more source

Climatology and inter-annual variability of the auroral MLT region inferred from the meteor radar observations during solar cycle 24 [PDF]

, 2017
15th MST Radar WorkshopSession M6: Middle atmosphere dynamics and structureMay 31 (Wed), NIPR ...

core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Role of Tropical easterly jet (TEJ) in stratospheric-troposphere exchange: Observations inferred from Indian MST Radar [PDF]

, 2017
15th MST Radar WorkshopSession M6: Middle atmosphere dynamics and structureMay 31 (Wed), NIPR ...

core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A review on meteor radar techniques for gravity wave observations in the mesosphere lower thermosphere [PDF]

, 2017
15th MST Radar WorkshopSession M6: Middle atmosphere dynamics and structureMay 31 (Wed), NIPR ...

core   +1 more source