Results 211 to 220 of about 107,170 (285)

Essential and toxic elements intake from botanical extracts: a probabilistic risk–benefit evaluation within the Italian dietary context

Journal of the Science of Food and Agriculture, Volume 106, Issue 7, Page 4060-4072, May 2026.
Abstract BACKGROUND Botanical extracts are widely consumed for their claimed health benefits, yet their safety profile with respect to chronic consumption remains poorly characterized. Understanding the potential health risks associated with their inorganic content is a crucial issue for ensuring safe use, along with a characterization of the ...
Giovanni Tommaso Lanza, Maria Olga Varrà, Lenka Husáková, Martina Piroutková, Jan Patočka, Emanuela Zanardi   +5 more
wiley   +1 more source

Theoretical framework and inference for fitting extreme data through the modified Weibull distribution in a first-failure censored progressive approach. [PDF]

Heliyon
Eliwa MS, Al-Essa LA, Abou-Senna AM, El-Morshedy M, El-Sagheer RM.   +4 more
europepmc   +1 more source

Development of a Predictive Flow Through Cell Dissolution Method for Carbamazepine Modified‐Release Tablets

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Predictive in vitro dissolution methods are crucial for anticipating in vivo drug performance, particularly for poorly soluble drugs like carbamazepine. In vitro‐in vivo correlations (IVIVC) link dissolution characteristics to pharmacokinetics, facilitating bioequivalence studies and reducing reliance on clinical trials.
Laura Carvajal Barbosa, Sandra Milena Echeverry, Diana Marcela Aragón   +2 more
wiley   +1 more source

Integration of Time‐Varying Pharmacometric Modeling With Cox Regression for Time‐to‐Event Analysis in NONMEM

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Although time‐varying Cox regression modeling approaches have been developed, exposure–response analyses for time‐to‐event (TTE) endpoints often rely on static exposure covariates and may overlook the real‐world dosing variability and drug concentration fluctuations over time. To better characterize pharmacokinetic (PK) or pharmacodynamic (PD)
Chih‐Wei Lin, Po‐Wei Chen, Sameer Doshi, Sandeep Dutta   +3 more
wiley   +1 more source

Improving Power of the Win Ratio Analysis through Distance‐based Weights

Statistics in Medicine, Volume 45, Issue 10-12, May 2026.
ABSTRACT The win ratio method, used to analyze composite endpoints in clinical trials, has gained substantial popularity in recent years because of its ability to prioritize components of the composite outcome. Despite gaining popularity and being extended to solve some of its issues, little work has been done to incorporate covariate information into ...
Md Rejuan Haque, Madison Hyer, Lai Wei, Xueliang Pan, Guy Brock   +4 more
wiley   +1 more source

A hierarchical Bayesian analysis for bivariate Weibull distribution under left-censoring scheme. [PDF]

J Appl Stat
Peralta D, de Oliveira RP, Achcar JA.
europepmc   +1 more source

Proportional Hazards Regression for Interval‐Censored Outcomes With an Interval‐Censored Covariate

Statistics in Medicine, Volume 45, Issue 10-12, May 2026.
ABSTRACT Identifying predictors for viral rebound trajectories after antiretroviral therapy (ART) interruption is central to HIV cure research. Motivated by the need to determine whether the time to achieve viral suppression after ART initiation can predict the time to viral rebound following ART interruption, we investigate modeling approaches that ...
Dongdong Li, Yue Song, Wenbin Lu, Huldrych F. Günthard, Roger Kouyos, Rui Wang   +5 more
wiley   +1 more source

Unprecedented Shifts in Hydrology Are Emerging Across California's Critical Basins: An Evaluation From 0.5 to 3.5°C

Water Resources Research, Volume 62, Issue 5, May 2026.
Abstract With advances in climate models and downscaling techniques, stakeholders anticipate high‐resolution analysis to inform regional to local changes in water management. Here, we produce hydrologic projections from an ensemble of Earth System Models (ESMs) that were selected and downscaled to support California's 5th Climate Assessment.
B. Bass, L. Su, D. Pierce, S. Rahimi, A. Hall, D. Cayan, W. Krantz, J. Kalansky, A. Rhoades, P. Ullrich   +9 more
wiley   +1 more source

Healthy Eating Index, Epigenetic Age Acceleration and Mortality Risk in US Adults

Aging Cell, Volume 25, Issue 5, May 2026.
Higher diet quality (HEI‐2015) was associated with lower epigenetic age acceleration and reduced all‐cause mortality in NHANES and HRS, with GrimAgeEAA emerging as the strongest mortality predictor and partially accounting for the diet–mortality association in HRS, within a broader framework linking socioeconomic status, behavioral factors, and ...
May A. Beydoun, Marie T. Fanelli Kuczmarski, Nicole Noren Hooten, Hind A. Beydoun, Jack Tsai, Ana I. Maldonado, Sharmin Hossain, Allen Nieva, Michele K. Evans, Alan B. Zonderman   +9 more
wiley   +1 more source