Results 51 to 60 of about 6,786,852 (260)

Structural Variants in the Human Genome Associated With Gut Microbiome and Blood Metabolic Traits With Potential Causal Links

Advanced Science, EarlyView.
Based on a multi‐omics cohort of 2002 individuals comprising high‐depth whole‐genome and metagenomic sequencing data, blood metabolites, and detailed questionnaires, we identified 138 859 high‐confidence SVs, uncovering 36 significant SV–microbiome associations and 48 SV–blood metabolite associations.
Qun Zhou, Keqing Wang, Junhong Chen, Haoyu Wang, Xinjiang Tan, Xuanlin Huang, Zhiyin Lin, Xun Xu, Xin Jin, Shaoqiao Zhang, Liang Xiao, Yuanqiang Zou, Tao Zhang, Xiaomin Liu   +13 more
wiley   +1 more source

Is systemic inflammation the missing link between the weight-adjusted waist index and hypertension? Results from the NHANES study

Blood Pressure
Background The weight-adjusted waist index (WWI) is a novel obesity measure standardizing waist circumference by body weight. While linked to cardiometabolic disorders, its association with hypertension (HTN) and the mediating role of systemic ...
Lijing Yang, Yi Hu, Siyu Chen, Lin Li
doaj   +1 more source

Forest Plot of Weight, BMI and Waist Circumference*.

, 2016
*weight = body weight in kg; BMI = Body Mass Index in kg/m2; Waist = waist circumference in cm.
Anthony W. Russell (758523), Dan J. Siskind (2838320), Steve Kisely (2838317), Daniel Wysoczanski (2838311), Janni Leung (2838314)   +4 more
core   +1 more source

Defining obesity cut-off points for migrant South Asians [PDF]

, 2011
<p><b>Background:</b> Body mass index (BMI) and waist circumference (WC) are used to define cardiovascular and type 2 diabetes risk. We aimed to derive appropriate BMI and WC obesity cut-off points in a migrant South Asian population ...
Brady Emer, Emer Brady (200466), Gray, L.J., Brady, E., Sattar, N., Melanie J Davies, David R Webb, David R. Webb, Sattar Naveed, Davies, M.J., Melanie J. Davies (7155500), Davies Melanie J., Laura J Gray, David R. Webb (200468), Khunti Kamlesh, Thomas Yates, Emer Brady, Kamlesh Khunti, Thomas Yates (171609), Webb David R., Webb, D.R., Yates Thomas, Kamlesh Khunti (171607), N. Sattar (7608890), Naveed Sattar, Khunti, K., Yates, T., Melanie J. Davies, Laura J. Gray, Gray Laura J., Laura J. Gray (7605071)   +30 more
core   +1 more source

Chronotype and Peripheral Clock Genes: Association With Frailty and Insomnia in Mexican Older Adults

AGING MEDICINE, EarlyView.
Chronotype, insomnia, frailty, and peripheral clock gene expression were evaluated in community‐dwelling older adults. Extreme morning chronotype was associated with lower odds of insomnia, whereas women showed higher odds of insomnia. Pre‐frail and frail participants exhibited lower peripheral clock gene expression patterns than robust individuals ...
Citlally E. Ortiz‐Vázquez, Paola Garcia‐delaTorre, Sergio Sánchez‐García, Lorena Aguilar‐Arnal, Lucía Mendoza‐Viveros   +4 more
wiley   +1 more source

Predictive Value of Traditional and Novel Obesity Indices for Stroke and Its Subtypes Across Sexes and Glucose Status: Toward Precision Prevention Strategies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background This study compared the predictive capacity of traditional and novel obesity indices for stroke subtype risks across sexes and glucose metabolic statuses, addressing limitations of current anthropometric tools.
Fang Li, Zhi‐yun Wang, Sha‐sha Qi, Yu‐ming Xu, Chang‐he Shi   +4 more
doaj   +1 more source

The CUN-BAE, Deurenberg Fat Mass, and visceral adiposity index as confident anthropometric indices for early detection of metabolic syndrome components in adults

Scientific Reports, 2022
There is no definition for the metabolic syndrome; visceral obesity, elevated lipids and glucose, and hypertension coexist. The aim of the study is to determine which anthropometric indicators best determine it.
A. A. López-González, A. Martínez Jover, C. Silveira Martínez, P. Martínez Artal, S. Arroyo Bote, Bárbara Altisench Jané, J. I. Ramírez-Manent   +6 more
doaj   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: The Study of Muscle, Mobility and Aging

Arthritis &Rheumatology, EarlyView.
Objective The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing in vastus lateralis muscle, resulting in 523 participants (56% female).
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

Crude and adjusted waist circumference, body mass index and waist-to-hip ratio z scores and type 2 diabetes hazards.

, 2015
*Adjusted for age, smoking status and alcohol drinking status.HR (Hazard ratio); 95%CI (95% confidence interval.Crude and adjusted waist circumference, body mass index and waist-to-hip ratio z scores and type 2 diabetes hazards.
Odewumi Adegbija (721251), Zhiqiang Wang (48987), Wendy Hoy (721252)   +2 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source