Results 91 to 100 of about 10,346,128 (298)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
BioPsychoSocial MedicineEating disorders can significantly impact the psychosocial functioning and physical health of adolescents. Early and effective treatment is crucial to prevent long-lasting and potentially devastating adverse effects. The National Institute for Health and
Riccardo Dalle Grave, Simona Calugi
doaj +1 more source
Total weight choosability in Hypergraphs [PDF]
, 2013 A total weighting of the vertices and edges of a hypergraph is called vertex-coloring if the total weights of the vertices yield a proper coloring of the graph, i.e., every edge contains at least two vertices with different weighted degrees. In this note
Pfender, Florian
core
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Online Importance Weight Aware Updates [PDF]
, 2011 An importance weight quantifies the relative importance of one example over another, coming up in applications of boosting, asymmetric classification costs, reductions, and active learning.
Karampatziakis, Nikos, Langford, John
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Journal of Materials Research and TechnologyIn this study, the CoCrFeNiMn0.75Cu0.25 high-entropy alloy (HEA) was systematically investigated to elucidate the effects of different annealing temperatures on the microstructure and mechanical properties of the face-centered cubic (fcc) structural ...
Wujing Fu +4 more
doaj +1 more source
Weight Discrimination: A Multidisciplinary Analysis [PDF]
, 2000 Protection against obesity discrimination is extremely limited under the Americans with Disabilities Act (ADA). No obese plaintiff has won using the actual disability theory, but a few have won under the perceived disability theory.
Maranto, Cheryl, Stenoien, Ann Fraedrich
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Barriers to Care for Pediatric Patients with Obesity
LifeThis review article emphasizes the challenges pediatric patients face during obesity treatment. Prior research has been compartmentalized, acknowledging that stigma, the ability to implement lifestyle changes, social health determinants, and healthcare ...
Sreevidya Bodepudi +4 more
doaj +1 more source