Results 231 to 240 of about 10,346,128 (298)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Effects of cariprazine on cholesterol, glucose, and weight in patients with schizophrenia: a systematic review and meta-analysis. [PDF]

Ther Adv Psychopharmacol
Berardelli I, Cifrodelli M, Mammoliti AV, Formica F, Iannazzo R, McIntyre RS, Pompili M.   +6 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

To Switch or not to Switch: are there any Antiretroviral Strategies to Attenuate Weight Gain in People with HIV? [PDF]

Curr HIV/AIDS Rep
Debroy P, Lake JE.
europepmc   +1 more source

Semaglutide Effects on Insulin Sensitivity and β-Cell Function in Patients With Schizophrenia, Prediabetes, and Obesity Treated With Second-Generation Antipsychotics: Findings From the HISTORI Trial, a 30-Week Randomized, Placebo-Controlled Trial With Semaglutide 1.0 mg Weekly. [PDF]

Diabetes Care
Ganeshalingam AA, Uhrenholt N, Arnfred S, Gæde P, Pedersen AK, Bilenberg N, Frystyk J.   +6 more
europepmc   +1 more source

One size does not fit all: Qualitative interviews with individuals with overweight or obesity and healthcare providers on navigating and supporting weight management. [PDF]

Obes Pillars
Stanford FC, Mojdami D, Edwards ML, Desai U, Hasan A, Holub A, Qu A, Mattera M, Ankerholz N, Sears E, Kirson N, Shinde S.   +11 more
europepmc   +1 more source

Brief Report: Dolutegravir-Based Therapy, Diet, Physical Activity, and Weight Gain: A 48-week Prospective Cohort in South Africa. [PDF]

J Acquir Immune Defic Syndr
Tien D, Chandiwana N, Shazi G, Chen G, Mabweazara S, Moosa MS, Gupta RK, Pillay D, Marconi VC, Hedt-Gauthier B, Venter WDF, Siedner MJ, McCluskey SM, Manne-Goehler J.   +13 more
europepmc   +1 more source

Multi-environment evaluation and genomic prediction of agronomic traits in the southern US rice genepool. [PDF]

Plant Genome
LaPorte MF, Hu H, Solomon W, Oard JH, Knapp SJ, Runcie DE, Edwards JD, McClung A, Diepenbrock CH.   +8 more
europepmc   +1 more source