Results 61 to 70 of about 3,690,704 (199)

Enhanced cognitive behaviour therapy for adolescents with eating disorders: development, effectiveness, and future challenges

BioPsychoSocial Medicine
Eating disorders can significantly impact the psychosocial functioning and physical health of adolescents. Early and effective treatment is crucial to prevent long-lasting and potentially devastating adverse effects. The National Institute for Health and
Riccardo Dalle Grave, Simona Calugi
doaj   +1 more source

Utility of BMIQ, a novel web‐based weight management programme, at an academic weight management centre

Obesity Science & Practice, 2020
Summary Background BMIQ is a customizable online platform used to deliver evidence‐based behavioural management that complements office visits with healthcare providers.
Sarah R. Barenbaum, Sherin E. Mathews, Katherine H. Saunders, Guadalupe Minero, Elizabeth Mauer, Louis J. Aronne, Alpana P. Shukla   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Probing deformation mechanisms of CoCrFeNiMn0.75Cu0.25 highentropy alloy after thermo-mechanical treatment using in situ EBSD investigation

Journal of Materials Research and Technology
In this study, the CoCrFeNiMn0.75Cu0.25 high-entropy alloy (HEA) was systematically investigated to elucidate the effects of different annealing temperatures on the microstructure and mechanical properties of the face-centered cubic (fcc) structural ...
Wujing Fu, Jingwei Ren, Guohua Fan, Xuewen Li, Yongjiang Huang   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Barriers to Care for Pediatric Patients with Obesity

Life
This review article emphasizes the challenges pediatric patients face during obesity treatment. Prior research has been compartmentalized, acknowledging that stigma, the ability to implement lifestyle changes, social health determinants, and healthcare ...
Sreevidya Bodepudi, Malikiya Hinds, Kayla Northam, Noreen A. Reilly-Harrington, Fatima Cody Stanford   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Influence of different rolling processes on microstructure, texture and anisotropy of the Al–Cu–Li alloy

Journal of Materials Research and Technology
Al–Cu–Li alloys have shown great potential for aerospace application due to their good combination of high strength and low density, but their high planar anisotropy have always hindered their application.
Fengman Li, Xiangyu Chen, Lipeng Ding, Chenglin Wang, Ke Zhang, Yaoyao Weng, Zhihong Jia   +6 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source