Results 101 to 110 of about 5,443,500 (289)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

On a more accurate half-discrete Hardy-Hilbert-type inequality related to the kernel of exponential function

Journal of Inequalities and Applications, 2016
By applying the weight functions, the technique of real analysis and Hermite-Hadamard’s inequality, a half-discrete Hardy-Hilbert-type inequality related to the kernel of exponential function with the best possible constant factor expressed by the gamma ...
Jianquan Liao, Bicheng Yang
doaj   +1 more source

Weighted Noncommutative Banach Function Spaces

, 2019
We review the concept of a weighted noncommutative Banach function space. This concept constitutes a generalisation of the by now well-known theory of noncommutative Banach function spaces associated with a semifinite von Neumann algebra. In this review we remind the reader of the quantum statistical problem which gave birth to this concept, we ...
Labuschagne, L.E., Steyn, C.
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A system-theory-based model for monthly river runoff forecasting: model calibration and optimization

Journal of Hydrology and Hydromechanics, 2014
River runoff is not only a crucial part of the global water cycle, but it is also an important source for hydropower and an essential element of water balance.
Wu Jianhua, Qian Hui, Li Peiyue, Song Yanxun   +3 more
doaj   +1 more source

On the Nemytskii Operator in the Space of Functions of Bounded (p, 2, α)-Variation with Respect to the Weight Function

Demonstratio Mathematica, 2014
In this paper, we consider the Nemytskii operator (Hf)(t) = h(t, f(t)), generated by a given function h. It is shown that if H is globally Lipschitzian and maps the space of functions of bounded (p,2,α)-variation (with respect to a weight function α ...
Aziz Wadie
doaj   +1 more source