Results 211 to 220 of about 7,387,955 (262)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

open access: yesFEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson   +2 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

open access: yesFEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito   +7 more
wiley   +1 more source
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The Weight Balance Function on Trees

Discrete Applied Mathematics, 2023
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Fred R. McMorris   +2 more
openaire   +1 more source

The Probability Weighting Function

Econometrica, 1998
Summary: A probability weighting function \(w(p)\) is a prominent feature of several non-expected utility theories, including prospect theory and rank-dependent models. Empirical estimates indicate that \(w(p)\) is regressive (first \(w(p)>p\), then \(w(p)
openaire   +2 more sources

OWA operators with functional weights

Fuzzy Sets and Systems, 2021
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jesús Medina 0001, Ronald R. Yager
openaire   +3 more sources

A weighted rotation function

Acta Crystallographica Section D Biological Crystallography, 1997
A simple probability expression is derived to discriminate the intermolecular vectors in the cross rotation function. The radial weighting function introduced takes into account both particle anisometry and crystal packing and can be incorporated into existing molecular replacement packages.
openaire   +3 more sources

Weighted chord functions

Pattern Recognition, 1988
Abstract The use of chord functions in shape recognition has been investigated by many authors, with most attention on the angle chord function as the metric chord function has weak discriminatory power. We introduce weighted chord functions which incorporate the metric information into the angle function.
openaire   +2 more sources

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