Results 101 to 110 of about 1,118,607 (313)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Improving Fourier Partial Sum Approximation for Discontinuous Functions Using a Weight Function

open access: yesAbstract and Applied Analysis, 2017
We introduce a generalized sigmoidal transformation wm(r;x) on a given interval [a,b] with a threshold at x=r∈(a,b). Using wm(r;x), we develop a weighted averaging method in order to improve Fourier partial sum approximation for a function having a jump ...
Beong In Yun
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Q-Dirichlet type L-functions with weight alpha [PDF]

open access: yes, 2013
The aim of this paper is to construct q-Dirichlet type L-functions with weight alpha. We give the values of these functions at negative integers.

core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Construction of Gaussian quadrature formulas for even weight functions [PDF]

open access: yes, 2017
Instead of a quadrature rule of Gaussian type with respect to an even weight function on (?a, a) with n nodes, we construct the corresponding Gaussian formula on (0, a2) with only [(n+1)/2] nodes. Especially, such a procedure is important in the
Mohammad Masjed-Jamei   +1 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Extensions of Simpson’s Inequality via Nonnegative Weight Functions and Fractional Operators

open access: yesAdvances in Mathematical Physics
MSC2020 Classification: 26A09, 26D10, 26D15 ...
Hasan Öğünmez, Mehmet Zeki Sarikaya
doaj   +1 more source

Executive functions of six-year-old boys with normal birth weight and gestational age.

open access: yesPLoS ONE, 2012
Impaired fetal development, reflected by low birth weight or prematurity, predicts an increased risk for psychopathology, especially attention deficit hyperactivity disorder (ADHD).
Desiree Yee-Ling Phua   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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