Results 141 to 150 of about 737,632 (262)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Olanzapine effectiveness on weight gain in anorexia nervosa patients: systematic review and meta-analysis. [PDF]

BMC Psychiatry
Alqurashi BF, Alserihi AR, Albariqi A, Alenazi AA, Alhindi Y, Alghamdi RL, Alotaibi BA, Abanmi SN, Alhejaili FA, Nahhas FH.   +9 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Determinants of Weight Gain in Forensic Psychiatric Care: A Protocol for a Systematic Review and Meta-Analysis. [PDF]

Campbell Syst Rev
Anthony J, Marcel-Davies J, Goodwin M.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Protocol for the development of the WHO gestational weight gain charts. [PDF]

BMJ Open
Rangel Bousquet Carrilho T, Oladapo OT, Hutcheon JA, Gatica-Domínguez G, Rasmussen KM, Flores-Urrutia MC, Kumapley R, Tunçalp Ӧ, Bahya-Batinda D, Fayed AA, Bogaerts A, Papageorghiou AT, Muñoz-Manrique C, Farias DR, Ohuma E, Sachdev H, Wahabi HA, Teede HJ, Johansson K, Bodnar LM, Wang M, Perumal N, Hasan SMT, Phelan S, Borghi E, Kac G.   +25 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Predictors of Weight Gain in Individuals Living with HIV on Antiretroviral Therapy: A Cross-Sectional Study. [PDF]

Nurs Rep
Medeiros THRES, de Ribamar Medeiros Lima Junior J, de Maria Pedrozo E Silva de Azevedo C, Di Leo Nogueira Costa L, Cristina Aranha Batista M, Costa Moraes F, Melo Ribeiro R, José Guimarães Gouveia A, de Lima Sardinha AH, Costa Rosa F, Soares Cunha M, de Mesquita LLS, Batalha Sena L, Fiterman Lima S, Falcai A.   +14 more
europepmc   +1 more source

Dietary Protein and Weight Gain

JAMA, 2012
openaire   +3 more sources