Results 131 to 140 of about 1,908,958 (312)
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Asthma and obesity: does weight loss improve asthma control? a systematic review [PDF]
, 2012 Caroline Trunk-Black Juel,1 Zarqa Ali,1 Lisbeth Nilas,2 Charlotte Suppli Ulrik11Respiratory Section, Internal Medicine Unit, 2Department of Obstetrics and Gynaecology, Hvidovre Hospital and University of Copenhagen, Hvidovre, DenmarkAim and methods ...
Ulrik CS, Juel CTB, Nilas L, Ali Z
core
Correction to: Preventing Peterson’s space hernia using a BIO synthetic mesh
BMC Surgery, 2021 Adam Skidmore, Edo O. Aarts
doaj +1 more source
Cardiovascular DiabetologyBackground The association between the triglyceride–glucose (TyG) index and subclinical left ventricular (LV) systolic dysfunction in obese patients remains unclear.
Guang-an Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Incentive Design to Enhance the Reach of Weight Loss Program [PDF]
This study employed stated-preference methods to elicit individuals’ program participation preference towards different financial incentive attributes. The results of this study show promise for the use of carefully designed incentive programs to raise ...
Parmeter, Christopher F. +5 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
WELLNESS AT WORK: WHAT INDIVIDUAL AND ORGANIZATIONAL FACTORS INFLUENCE PARTICIPATION IN AND ADHERENCE TO A WORKPLACE WEIGHT LOSS (WEIGHT WATCHERS) PROGRAM? [PDF]
, 2015 Obesity is a health concern for Canadians. Workplace weight loss programs are demonstrating promising outcomes with managing obesity. However, participation and adherence is problematic, especially for those employees most at risk (e.g., shift workers ...
Brenton-Peters, Jennifer
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source