Results 41 to 50 of about 1,647,336 (269)

Perspectives into the experience of successful, substantial long-term weight-loss maintenance: a systematic review

International Journal of Qualitative Studies on Health & Well-Being, 2021
Purpose: In light of the increasing prevalence of overweight and obesity, understanding the experiences, strategies and challenges encountered when trying to achieve substantial, sustainable weight loss is an important area to investigate.
Marie Spreckley, Jaap Seidell, Jutka Halberstadt   +2 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Carbohydrate reduction for metabolic disease is distinct from the ketogenic diet for epilepsy

Journal of Metabolic Health
Recent reviews of using therapeutic carbohydrate reduction to treat metabolic disease in paediatric patients have consistently made errors in the form of bias against recommending this nutrient-dense eating pattern despite strong evidence for its use in ...
Matthew Calkins, Laura Buchanan, Tro Kalayjian, David Dikeman, Mark Cucuzzella, Eric Westman   +5 more
doaj   +1 more source

Assessment of Physical Fitness after Bariatric Surgery and Its Association with Protein Intake and Type of Cholecalciferol Supplementation

Medicina, 2019
Background and objectives: Several studies showed that there is a relationship between vitamin and mineral status and muscle strength. In particular this is the case for handgrip strength (HS) and vitamin D deficiency.
Hendrika J. M. Smelt, Sjaak Pouwels, Alper Celik, Adarsh Gupta, Johannes F. Smulders   +4 more
doaj   +1 more source

Weight loss-induced improvement of body weight and insulin sensitivity is not amplified by a subsequent 12-month weight maintenance intervention but is predicted by adaption of adipose atrial natriuretic peptide system: 48-month results of a randomized controlled trial [PDF]

, 2022
Linna Li, Dominik Soll, Verena Leupelt, Joachim Spranger, Knut Mai   +4 more
openalex   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Improved metabolic syndrome and timing of weight loss is crucial for influenza vaccine-induced immunity in obese mice [PDF]

, 2022
Rebekah Honce, Ana Vazquez-Pagan, Brandi Livingston, Sean Cherry, Virginia Hargest, Bridgett Sharp, Lee-Ann Van de Velde, R. Chris Skinner, Paul G. Thomas, Stacey Schultz‐Cherry   +9 more
openalex   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Obesidad, el papel del gastroenterólogo

Revista Colombiana de Gastroenterología
Antecedentes: la obesidad es una enfermedad con alta prevalencia a nivel mundial, y su incidencia está en aumento, especialmente en los países de ingresos medios a altos. Su fisiopatología se encuentra relacionada con la regulación hormonal intestinal y
Valeria Atenea Costa Barney, Daniela Caceres, Alfonso Kerguelen, Jesus Rodriguez, Andres Rodriguez, Manoel Galvao Neto   +5 more
doaj   +1 more source