Results 91 to 100 of about 3,977,256 (299)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
MetalsThe automotive industry is undergoing a rapid evolution to meet today’s challenges; therefore, continuous innovation and product development are needed.
Silvia Cecchel, Giovanna Cornacchia
doaj +1 more source
Effects of Bariatric Surgery on Facial Features
Archives of Plastic Surgery, 2015 Background Bariatric surgeries performed in the USA has increased twelve-fold in the past two decades. The effects of rapid weight loss on facial features has not been previously studied.
Vardan Papoian +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Weight reduction for quantum codes [PDF]
Quantum Information and Computation, 2017 We present an algorithm that takes a CSS stabilizer code as input, and outputs another CSS stabilizer code such that the stabilizer generators all have weights O(1) and such that O(1) generators act on any given qubit. The number of logical qubits is unchanged by the procedure, while we give bounds on the increase in number of physical qubits and in ...
openaire +2 more sources
High-performance RC bandpass filter is adapted to miniaturized construction [PDF]
, 1966 Miniaturized bandpass filter with RC networks is suitable for use in integrated circuits. The circuit consists of three stages of amplification with additional resistive and capacitive components to obtain the desired characteristics.
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Effect of gender, nationality and attitudes on weight reduction strategies [PDF]
Health Economics and Policy,
Grebitus, Carola +2 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
A Mechanism of Polymer Induced Drag Reduction in Turbulent Pipe [PDF]
, 2014 Polymer induced drag reduction in turbulent pipe flow was investigated using a non-intrusive laser based diagnostic technique, namely Particle Image Velocimetry (PIV).
Markides, CN, Zadrazil, I
core +1 more source