Results 191 to 200 of about 3,977,256 (299)

The effect of orlistat on body weight in obese Czech adults

Open Medicine, 2013
Pavlík Vladimír, Fajfrová Jana, Drahokoupilová Eva   +2 more
doaj   +1 more source

Efficacy of antiobesity medications for weight reduction in older adults: a systematic review. [PDF]

Obesity (Silver Spring)
Chen AS, Hajduk AM, Grimshaw AA, Fried TR, Jastreboff AM, Lipska KJ.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Understanding the clinical characteristics associated with health care costs and cost savings upon weight reduction in individuals with obesity or overweight. [PDF]

Diabetes Obes Metab
Li X, Vallarino C, Denning M, Gibble TH, Schapiro D, Liu D, Li A, Ward JM, Pearson-Stuttard J.   +8 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Weight reduction over time in tirzepatide-treated participants by early weight loss response: Post hoc analysis in SURMOUNT-1. [PDF]

Diabetes Obes Metab
Ard J, Lee CJ, Gudzune K, Addison B, Lingvay I, Cao D, Mast CJ, Stefanski A, Falcon B, Mojdami D.   +9 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

One anastomosis gastric bypass produces considerable weight reduction and resolution of medical complications with an acceptable rate of nutritional deficiencies. [PDF]

Sci Rep
Al-Hasani W, Ranasinghe R, Chin YH, Chew HSJ, Mazahiri T, Herath N, Lajeunesse-Trempe F, Roser P, Grady S, Lee A, Altmeyer R, Chew NWS, Vincent RP, El-Hasani S, Dimitriadis GK.   +14 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The impact of oral semaglutide on glycemic control and weight reduction: a database analysis of dosing effects in Japanese individuals with type 2 diabetes. [PDF]

Front Endocrinol (Lausanne)
Ishiguro M, Nishimura R.
europepmc   +1 more source