Results 71 to 80 of about 3,977,256 (299)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Goal-directed versus outcome-based financial incentives for weight loss among low-income patients with obesity: rationale and design of the Financial Incentives foR Weight Reduction (FIReWoRk) randomised controlled trial. [PDF]
, 2019 IntroductionObesity is a major public health challenge and exacerbates economic disparities through employment discrimination and increased personal health expenditures. Financial incentives for weight management may intensify individuals' utilisation of
Goldstein, Noah J +9 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
New antagonist agents of neuropeptide y receptors
Química Nova, 2000 In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana +8 more
doaj +1 more source
System technology analysis of aeroassisted orbital transfer vehicles. Moderate lift/drag (0.75-1.5): Volume 1A, part 2: Executive summary, phase 2 [PDF]
Significant achievements and activities of Phase 2 of a study to assess aeroassisted orbit transfer vehicle (AOTV) system technology are summarized. Phase 2 was directed towards identification and prioritization of technology payoffs of representative ...
core +1 more source
Sources, control, and effects of noise from aircraft propellers and rotors [PDF]
, 1981 Source noise predictions are compared with measurements for conventional low-speed propellers, for new high speed propellers (propfans), and for a helicopter.
Dempsey, T. K. +2 more
core +2 more sources
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
What is the point of reduction in science? [PDF]
, 2018 The numerous and diverse roles of theory reduction in science have been insufficiently explored in the philosophy literature on reduction. Part of the reason for this has been a lack of attention paid to reduction2 (successional reduction)---although I ...
Crowther, Karen
core +2 more sources
Low-temperature transport in Heisenberg chains
, 2002 A technique to determine accurately transport properties of integrable and non-integrable quantum-spin chains at finite temperatures by Quantum Monte-Carlo is presented.
A. Rosch +21 more
core +1 more source