Results 41 to 50 of about 1,145,184 (278)

Weighted geometric set multi-cover via quasi-uniform sampling

Journal of Computational Geometry, 2016
We give a randomized polynomial time algorithm with approximation ratio $O(\log \phi(n))$ for weighted set multi-cover instances with a shallow cell complexity of at most $f(z,k) =z\phi(z) k^{O(1)}$.
Nikhil Bansal, Kirk Pruhs
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Decision-Making Approach under Pythagorean Fuzzy Yager Weighted Operators

Mathematics, 2020
In fuzzy set theory, t-norms and t-conorms are fundamental binary operators. Yager proposed respective parametric families of both t-norms and t-conorms. In this paper, we apply these operators for the analysis of Pythagorean fuzzy sets. For this purpose,
Gulfam Shahzadi, Muhammad Akram, Ahmad N. Al-Kenani   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fault-Tolerant Additive Weighted Geometric Spanners [PDF]

, 2019
Let S be a set of n points and let w be a function that assigns non-negative weights to points in S. The additive weighted distance d_w(p, q) between two points p,q belonging to S is defined as w(p) + d(p, q) + w(q) if p \ne q and it is zero if p = q. Here, d(p, q) denotes the (geodesic) Euclidean distance between p and q. A graph G(S, E) is called a t-
Sukanya Bhattacharjee, R. Inkulu
openaire   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

MABAC framework for logarithmic bipolar fuzzy multiple attribute group decision-making for supplier selection

Complex & Intelligent Systems, 2023
In this article, we introduce logarithmic operations on bipolar fuzzy numbers (BFNs). We present some new operators based on these operations, namely, the logarithm bipolar fuzzy weighted averaging (L-BFWA) operator, logarithm bipolar fuzzy ordered ...
Chiranjibe Jana, Harish Garg, Madhumangal Pal, Biswajit Sarkar, Guiwu Wei   +4 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Reciprocal fraction function tools used for \-rung Quadripartitioned neutrosophic sets [PDF]

Neutrosophic Sets and Systems
This paper presents a new method for creating a \-rung reciprocal fraction function. We introduce quadripartitioned neutrosophic sets (QNSS). The reciprocal fraction function applied to quadripartitioned neutrosophic sets are the neutrosophic sets and ...
M.Palanikumar, Nasreen Kausar , Dina Said   +2 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source