Results 121 to 130 of about 1,255,445 (300)
FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source
Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells
FEBS Open Bio, EarlyView.Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley +1 more source
FEBS Open Bio, EarlyView.The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao +23 more
wiley +1 more source
Ranking of nodes in the mathematical portal Math-Net.ru publications graph
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015 We propose a new method for determining betweenness centraity for weighted graphs based on Kirchhoff's law. This method has low computational complexity. The results of numerical experiments are presented for the coauthors graph from the math portal Math-
Bulat Tsynguev +2 more
doaj +1 more source
Overlapping communities detection through weighted graph community games. [PDF]
PLoS One, 2023 Benati S +3 more
europepmc +1 more source
An Explainable Geometric-Weighted Graph Attention Network for Identifying Functional Networks Associated with Gait Impairment. [PDF]
Med Image Comput Comput Assist Interv, 2023 Nerrise F +4 more
europepmc +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
iPiDA-SWGCN: Identification of piRNA-disease associations based on Supplementarily Weighted Graph Convolutional Network. [PDF]
PLoS Comput Biol, 2023 Hou J, Wei H, Liu B.
europepmc +1 more source
Optimization Mode Research of Weighted Undirected Graph [PDF]
, 2020 . An algorithm is described for constructing a weighted undirected graph structure, based on the principle of directed acyclic graph, used the improved Floyd algorithm to improve the multi-node version of the evolution of information in order to release ...
Wei Fan, Qian Xing, Feng Liu, Hong Wang
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source