Results 51 to 60 of about 790,504 (291)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Synthesis of a Uniformly Spaced Array with Symmetric Amplitude Excitation by a Weighted Least-Square Method

Sultan Qaboos University Journal for Science, 2007
A new, non-iterative  technique for synthesizing equispaced linear arrays with symmetric excitation is proposed. The methods is on the computation of an  eigenvector of an appropriate real, Symmetric and positive-definite matrix.
J.A. Jervase, I.H. Zabalawi
doaj   +1 more source

Electrospun nanofiber membrane diameter prediction using a combined response surface methodology and machine learning approach

Scientific Reports, 2023
Despite the widespread interest in electrospinning technology, very few simulation studies have been conducted. Thus, the current research produced a system for providing a sustainable and effective electrospinning process by combining the design of ...
Md. Nahid Pervez, Wan Sieng Yeo, Mst. Monira Rahman Mishu, Md. Eman Talukder, Hridoy Roy, Md. Shahinoor Islam, Yaping Zhao, Yingjie Cai, George K. Stylios, Vincenzo Naddeo   +9 more
doaj   +1 more source

PENERAPAN METODE WEIGTHED LEAST SQUARE UNTUK MENGATASI HETEROSKEDASTISITAS PADA ANALISIS REGRESI LINEAR [PDF]

, 2016
Analisis regresi merupakan analisis statistik yang mempalajari bagaimana memodelkan regresi linear. Jika model regresi linear memenuhi uji asumsi klasik dengan metode OLS maka mempunyai sifat BLUE (Beast Linear Unbiased Estimator).
Hanifah, Nurul
core  

Penalized Composite Quasi-Likelihood for Ultrahigh-Dimensional Variable Selection

, 2010
In high-dimensional model selection problems, penalized simple least-square approaches have been extensively used. This paper addresses the question of both robustness and efficiency of penalized model selection methods, and proposes a data-driven ...
Bai, Bickel, Bickel, Bickel, Deutsch, Efron, Fan, Fan, Fan, Fan, Fan, Frank, Friedman, Huang, Huber, Kim, Koenker, Lehmann, Li, Portnoy, Portnoy, Tibshirani, van der Vaart, Wu, Xie, Yuan, Zhao, Zou, Zou, Zou, Zou   +30 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Research on a robust positioning algorithm for mine proximity detectio

Gong-kuang zidonghua, 2018
In view of problems of existing positioning algorithms for mine proximity detection that ranging error is large due to non-line-of-sight and other factors, and solution of ranging equation set does not converge under complex conditions, a robust ...
CHEN Kang, BAO Jianjun, WANG Wei
doaj   +1 more source

Robust algorithm for calibration of robotic manipulator model [PDF]

, 2013
The paper focuses on the robust identification of geometrical and elastostatic parameters of robotic manipulator. The main attention is paid to the efficiency improvement of the identification algorithm.
ABBA, Gabriel, FURET, Benoit, GARNIER, Sébastien, KLIMCHIK, Alexandr, PASHKEVICH, Anatol, WU, Yier   +5 more
core   +7 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source