Results 51 to 60 of about 1,053,925 (307)

Multilevel weighted least squares polynomial approximation [PDF]

open access: yesESAIM: Mathematical Modelling and Numerical Analysis, 2017
Weighted least squares polynomial approximation uses random samples to determine projections of functions onto spaces of polynomials. It has been shown that, using an optimal distribution of sample locations, the number of samples required to achieve ...
A. Haji-Ali   +3 more
semanticscholar   +1 more source

Combinatorics of least squares trees [PDF]

open access: yes, 2008
A recurring theme in the least squares approach to phylogenetics has been the discovery of elegant combinatorial formulas for the least squares estimates of edge lengths.
Mihaescu, Radu, Pachter, Lior
core   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Strong Consistency of Estimators in a Partially Linear Model with Asymptotically Almost Negatively Associated Errors

open access: yesDiscrete Dynamics in Nature and Society, 2020
This paper studies a heteroscedastic partially linear regression model in which the errors are asymptotically almost negatively associated (AANA, in short) random variables with not necessarily identical distribution and zero mean.
Yu Zhang, Xinsheng Liu, Mohamed Sief
doaj   +1 more source

Monotonic Properties of the Least Squares Mean

open access: yes, 2010
We settle an open problem of several years standing by showing that the least-squares mean for positive definite matrices is monotone for the usual (Loewner) order.
Lawson, Jimmie, Lim, Yongdo
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Weighted total least squares formulated by standard least squares theory [PDF]

open access: yesJournal of Geodetic Science, 2012
Weighted total least squares formulated by standard least squares theoryThis contribution presents a simple, attractive, and flexible formulation for the weighted total least squares (WTLS) problem. It is simple because it is based on the well-known standard least squares theory; it is attractive because it allows one to directly use the existing body ...
A. Amiri-Simkooei, S. Jazaeri
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

On weighted total least squares adjustment for solving the nonlinear problems

open access: yesJournal of Geodetic Science, 2014
In the classical geodetic data processing, a non- linear problem always can be converted to a linear least squares adjustment. However, the errors in Jacob matrix are often not being considered when using the least square method to estimate the optimal ...
Hu C., Chen Y., Peng Y.
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

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