Results 111 to 120 of about 903,926 (277)
Forest fire risk zone mapping in the Golestan national park using weighted linear combination (WLC) method [PDF]
مجله جنگل ایران, 2014 Forest fires in the Iran and particularly in the northern forests had destructive effects on the physiognomy of these forests. Forest fire risk zone mapping in forest lands is one of the main approaches of recognition and prevention by applied and ...
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Combining HMM and Weighted Deviation Linear Transformation for Highband Speech Parameter Estimation
IEICE Transactions on Information and Systems, 2009 A hidden Markov model (HMM)-based parameter estimation scheme is proposed for wideband speech recovery. In each Markov state, the estimation efficiency is improved using a new mapping function derived from the weighted least squares of vector deviations.
Hwai-Tsu HU, Chu YU
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Agricultural Economics (AGRICECON), 2009 The aim of the paper is to present a developed spreadsheet tool for the formulation of a daily dairy cow ration. It is constructed on the basis of two linked sub-models developed on the MS Excel platform. It merges the common linear programming model and
J. Žgajnar, L. Juvančič, S. Kavčič
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
To Combine Forecasts or to Combine Information? [PDF]
When the objective is to forecast a variable of interest but with many explanatory variables available, one could possibly improve the forecast by carefully integrating them. There are generally two directions one could proceed: combination of forecasts (
Huiyu Huang, Tae-Hwy Lee
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source