Results 101 to 110 of about 235,360 (278)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

On interpolation of operator, which is the sum of weighted Hardy-Littlewood and Cesaro mean operators

Researches in Mathematics, 2019
It is proved that operators, which are the sum of weighted Hardy-Littlewood $\int\limits_0^1 f(xt) \psi(t) dt$ and Cesaro $\int\limits_0^1 f(\frac{x}{t}) t^{-n} \psi(t) dt$ mean operators, are limited on Lorentz spaces $\Lambda_{\varphi, a} (\mathbb{R})$,
B.I. Peleshenko
doaj   +1 more source

Distance measures, weighted averages, OWA operators and Bonferroni means

Applied Soft Computing, 2017
We would like to thank the editor-in-chief, the associate editor and the anonymous reviewers for valuable comments that have improved the quality of the paper. Support from the project PIEF-GA-2011-300062 from the European Commission and from the University of Chile is gratefully ...
José M. Merigó, Daniel Palacios-Marqués, Pedro Soto-Acosta   +2 more
openaire   +3 more sources

Sharp Bounds for a Generalized Logarithmic Operator Mean and Heinz Operator Mean by Weighted Ones of Classical Operator Ones

Mathematics, 2022
In this paper, using a criteria for the monotonicity of the quotient of two power series, we present some sharp bounds for a generalized logarithmic operator mean and Heinz operator mean by weighted ones of classical operator ones.
openaire   +2 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Dual Hesitant Pythagorean Fuzzy Heronian Mean Operators in Multiple Attribute Decision Making

Mathematics, 2019
On account of the indeterminacy and subjectivity of decision makers (DMs) in complexity decision-making environments, the evaluation information over alternatives presented by DMs is usually fuzzy and ambiguous.
Mei Tang, Jie Wang, Jianping Lu, Guiwu Wei, Cun Wei, Yu Wei   +5 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Dombi power partitioned Heronian mean operators of q-rung orthopair fuzzy numbers for multiple attribute group decision making.

PLoS ONE, 2019
In this paper, a set of Dombi power partitioned Heronian mean operators of q-rung orthopair fuzzy numbers (qROFNs) are presented, and a multiple attribute group decision making (MAGDM) method based on these operators is proposed.
Yanru Zhong, Hong Gao, Xiuyan Guo, Yuchu Qin, Meifa Huang, Xiaonan Luo   +5 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Fuzzy Aggregation for Multi-Sensor Indoor Localization: Integrating Heterogeneous Data Sources

IEEE Access
Indoor localization is a crucial technology for applications such as intelligent building management, security, navigation, etc. However, the presence of complexities and uncertainties in the sensor data invites multiple challenges while integrating the ...
Qingyu Ci
doaj   +1 more source