Results 191 to 200 of about 463,737 (318)

Utilization of sequential model-based optimizer integrated machine learning models in correlation of famotidine solubility in supercritical carbon dioxide. [PDF]

Sci Rep
Alotaibi HF, Hsu CY, Sead FF, Yadav A, Jyothi RS, Mishra S, Purohit B, Khudaynazarov E, Yaxshimuratov M, Chauhan AS.   +9 more
europepmc   +1 more source

Application of Weighted Empirical Orthogonal Function Analysis to ship's datasets

, 2002
Marine ship observations over the vast oceanic regions are crucial to studies of climate variability on timescales from the seasonal to multidecadal. However, any climatic analysis of this historical record is hampered by two difficult problems, namely:- The systematic instrumental errors which contaminate the ship observations. For example, it is well-
openaire   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Hypergraph-based decay analysis for predicting and classifying states beyond regge trajectories. [PDF]

PLoS One
Gao J.
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Contrastive report and multiparametric dual-region magnetic resonance imaging learning for the preoperative prediction of axillary lymph node metastasis in breast cancer. [PDF]

Quant Imaging Med Surg
Shen H, Cui W, Peng Y, Leng Y, Zhang X, Yuan G, Zheng J.   +6 more
europepmc   +1 more source

Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment

Advanced Science, EarlyView.
ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao, Dalin Chen, Ziyi Zhang, Jingxuan Ren, Chengcheng Zhao, Shengfang Wang, Mengyu Shang, Dawei Jiang, Yinuo Li, Su'an Tang, Kai Li, Xiaohui Zhang, Xiaogang Wang   +12 more
wiley   +1 more source

Exploration of schizophrenia-associated gene modules using graph theory, co-expression networks, and dimensionality reduction. [PDF]

PLoS One
Bampos C, Megalooikonomou V.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Long-term perceptual priors drive confidence bias that favors prior-congruent evidence. [PDF]

PLoS Comput Biol
Constant M, Filevich E, Mamassian P.
europepmc   +1 more source