Results 41 to 50 of about 21,411 (263)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Sums of weighted composition operators on H∞

open access: yes, 2011
We characterize compactness of sums of weighted composition operators on the Banach algebra of bounded analytic functions on the open unit ...
Izuchi, Kei Ji   +3 more
core   +1 more source

On the strong convergence for weighted sums of asymptotically almost negatively associated random variables [PDF]

open access: yes, 2014
summary:Applying the moment inequality of asymptotically almost negatively associated (AANA, in short) random variables which was obtained by Yuan and An (2009), some strong convergence results for weighted sums of AANA random variables are obtained ...
Deng, Guangming   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Sums of Weighted Lattice Points of Polytopes

open access: yes, 2023
We study the problem of counting lattice points of a polytope that are weighted by an Ehrhart quasi-polynomial of a family of parametric polytopes. As applications one can compute integrals and maximum values of such quasi-polynomials, as well as obtain new identities in representation theory.
De Loera, Jesús A.   +3 more
openaire   +3 more sources

Tail Behavior of Randomly Weighted Sums [PDF]

open access: yesAdvances in Applied Probability, 2012
Let {Xt, t ≥ 1} be a sequence of identically distributed and pairwise asymptotically independent random variables with regularly varying tails, and let {Θt, t ≥ 1} be a sequence of positive random variables independent of the sequence {Xt, t ≥ 1}. We will discuss the tail probabilities and almost-sure convergence of X(∞) = ∑t=1∞ΘtXt+ (where X+ = max{0,
Hazra, Rajat Subhra, Maulik, Krishanu
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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