Results 151 to 160 of about 17,802 (285)
USSR Space Life Sciences Digest [PDF]
Research in exobiology, life sciences technology, space biology, and space medicine and physiology, primarily using data gathered on the Salyut 6 orbital space station, is reported.
Donnelly, K. L., Lewis, C. S.
core +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Motion sickness precipitated in the weightless phase of parabolic flight by Coriolis accelerations [PDF]
Human motion sickness susceptibility when exposed to Coriolis accelerations during parabolic flight ...
Graybiel, A. +2 more
core +1 more source
A new strategy for constructing microgravity culture environment via gas-liquid coupled oscillatory flow field. [PDF]
NPJ MicrogravityWang C, Qiang Y, Wei L.
europepmc +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
NASA space biology accomplishments, 1982 [PDF]
Summaries of NASA's Space Biology Program projects are provided. The goals, objectives, accomplishments, and future plans of each project are described in this publication as individual technical ...
Halstead, T. W., Pleasant, L. G.
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Computer simulation of preflight blood volume reduction as a countermeasure to fluid shifts in space flight [PDF]
Fluid shifts in weightlessness may cause a central volume expansion, activating reflexes to reduce the blood volume. Computer simulation was used to test the hypothesis that preadaptation of the blood volume prior to exposure to weightlessness could ...
Charles, J. B. +2 more
core +1 more source
Neck-vein thrombosis during spaceflight. [PDF]
Br J Clin PharmacolLimper U, Jordan J.
europepmc +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source