Results 91 to 100 of about 2,683,768 (284)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Weighted Lagrange and Hermite–Fejér interpolation on the real line
Journal of Inequalities and Applications, 1997 For a wide class of weights, a systematic investigation of the convergence-divergence behavior of Lagrange interpolation is initiated. A system of nodes with optimal Lebesgue constant is found, and for Hermite weights an exact lower estimate of the norm
Szabados J
doaj
STOCHASTIC MULTI-ATTRIBUTE UTILITY MODEL
Acta Economica, 2019 In real situations, the attribute value (mostly variable) can be best represented by introducing the finite number of attribute values level, to which the corresponding probabilities should also be attached.
Katarina Račić +3 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Наука Красноярья, 2013 В статье исследовано понятие внешнеэкономической безопасности, обоснована система индикаторов внешнеэкономической безопасности регионов, определенны их предельные значения, предложен методологический подход к определению уровня интегрального индикатора ...
Н. А. Резник
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Bloom-type two-weight inequalities for commutators of maximal functions
Analysis and Geometry in Metric SpacesWe study Bloom-type two-weight inequalities for commutators of the Hardy-Littlewood maximal function and sharp maximal function. Some necessary and sufficient conditions are given to characterize the two-weight inequalities for such commutators.
Zhang Pu, Fan Di
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Weighted Context-Free Grammars Over Bimonoids
Scientific Annals of Computer Science, 2019 We introduce and investigate weighted context-free grammars over an arbitrary bimonoid K. Thus, we do not assume that the operations of K are commutative or idempotent or they distribute over each other.
George Rahonis, Faidra Torpari
doaj +1 more source