Results 131 to 140 of about 1,214,495 (311)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

OPTIMAL HOG SLAUGHTER WEIGHTS UNDER ALTERNATIVE PRICING SYSTEMS [PDF]

Three hog genotypes are simulated to determine how producer profits, economically optimal slaughter weights, and carcass component weights change under three pricing models.
Boland, Michael A., Preckel, Paul V., Schinckel, Allan P.   +2 more
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Prioritizing of Criteria in Teacher-Candidate Selection Process by Analytic Hierarchy Process

International Journal of Management Studies, 2013
This paper reviews and identifies the criteria used in the teacher-candidate selection process. The identified main criteria and sub-criteria were prioritized according to their importance by a group of experts.
Maznah Mat Kasim, Razamin Ramli, Haslinda Ibrahim, Mohd Izam Ghazali, Fazillah Mohmad Kamal, S. Vikneswari   +5 more
doaj  

Performance Assessment of Existing Asphalt Pavement in China’s Highway Reconstruction and Expansion Project Based on Coupling Weighting Method and Cloud Model Theory

Applied Sciences
In China, a substantial portion of highway asphalt pavements are no longer capable of accommodating increasing traffic volumes and necessitate renovation and expansion. Prior to commencing such activities, it is crucial to evaluate the performance of the
Ying Xu, Xixin Shi, Yongsheng Yao
doaj   +1 more source

WP 60 - Sample bias, weights and efficiency of weights in a continuous web voluntary survey [PDF]

Using micro data from a continuous voluntary web survey, the Wage Indicator, the paper analyses the type of bias that such a sampling method produces and discusses a methodology to weight the data in order to correct such bias and make it possible to run
Muñoz de Bustillo, Rafael, Kea Tijdens, Pedraza, Pablo de   +2 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source