Results 171 to 180 of about 3,527,904 (336)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Palliative Care: Symptom Management and end of Life Care [PDF]

open access: yes, 2007
Ministry of Health and Social Welfare, (MoHSW)
core  

Welfare Stigma Allowing for Psychological and Cultural Effects. An Agent-Based Simulation Study [PDF]

open access: yes
We investigate the effects of income support on unemployment and welfare dynamics when stigma is attached to welfare provision. Stigma has been modelled in the literature as a cost of entry into welfare. Allowing for psychological factors, we assume that
Dalit Contini, Matteo Richiardi
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

WELFARISM VS EXTRA-WELFARISM

open access: yesKöz-gazdaság, 2020
Tony Culyer az egészség-gazdaságtan tudományág egyik létrehozója az Institute for Work & Health vezetõ kutatója Torontóban, az egészség-gazdaságtan professzora a York-i egyetemen Angliában és a torontói egyetem vendég professzora, a Journal of Health Economics társszerkesztõje illetve számos más szakmai újság szerkesztõ bizottságának tagja.
openaire   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

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