Results 131 to 140 of about 2,120,854 (294)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Development of a welfare assessment protocol for dromedary camels during road transport
Frontiers in Veterinary ScienceTransporting dromedary camels, like other farm animals, may be stressful and impair their welfare and health. The lack of standardized practices regarding loading and unloading, vehicle design and size, journey duration, and space allowance complicates ...
Barbara Padalino +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
, 1960 These biennial reports are summaries of the activities of this agency. They were extracted from a series of Kansas agency reports covering over 100 state agencies and institutions bound together for each biennium, 1959/1960 - 1979/1980.
Kansas. State Department of Social Welfare.
core +1 more source
Journal of Dairy Science: Dairy calf welfare assessment tools focusing on the preweaning period have been proposed in recent research. Despite the existence of these tools, assessing the welfare and health-related quality of life (HRQoL) of dairy calves remains challenging ...
Jean Ramos +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
, 1934 Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core
Animal WelfareGood welfare is of inherent value to all captive animals and promotes species conservation objectives. Concern for animal welfare is growing globally, and research shows that animal welfare is a top priority for zoo visitors.
Niamh Mc Gill +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
, 1933 Annual; Report year varies; issue for calendar year ending 1940 includes fiscal year ending June 30, 1940.; Volumes for 1931-1933 issued by the Bureau of Child Welfare; volumes for 1934- by the Office of Commissioner of ...
Connecticut. Bureau of Child Welfare.
core