Results 171 to 180 of about 2,883,415 (350)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Using the Welfare Quality® framework to develop a welfare assessment protocol for captive chimpanzees (Pan troglodytes)

Animal Welfare
Good welfare is of inherent value to all captive animals and promotes species conservation objectives. Concern for animal welfare is growing globally, and research shows that animal welfare is a top priority for zoo visitors.
Niamh Mc Gill, Miguel Bueno, Neil E. Anderson   +2 more
doaj   +1 more source

Effects of weaning and 48 h transport by road and ferry on some blood indicators of welfare in lambs

, 2008
N Tadich, Carmen Gallo, Maria Lúcia Valada de Brito, Donald M. Broom   +3 more
openalex   +2 more sources

Risk factors associated with indicators of dairy cow welfare during the housing period in Irish, spring-calving, hybrid pasture-based systems

, 2022
R.E. Crossley, E.A.M. Bokkers, Natasha Browne, Katie Sugrue, E. Kennedy, M. Conneely   +5 more
openalex   +1 more source

Indicators of broiler welfare during transport

Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies
Transportation is one of the most stressful stages in the broiler production cycle. Violations of transport conditions can lead to a significant deterioration in the birds' physiological state, increased stress levels, injuries, reduced meat quality, and economic losses due to broiler mortality.
I. Indutna, I. O. Kolomak, O. O. Peredera, I. V. Lavrinenko   +3 more
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The Weekly Adjustment Indicators Checklist: An Application in the Child Welfare Field

, 1998
Michael H. Epstein, Madhavi Jayanthi, Janet McKelvey, Deborah Holderness, Erin Frankenberry   +4 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Defining and measuring indicators of successful transitions for youth aging out of child welfare systems: A scoping review and narrative synthesis

, 2022
Sabrina Agnihotri, Caroline Park, Roland M. Jones, Deborah Goodman, Mitesh Patel   +4 more
openalex   +1 more source

Human Development: beyond the HDI [PDF]

The well-known Human Development Index (HDI) encompasses only three rather basic aspects of human welfare. This paper aims to go beyond this, by identifying 11 categories of human development.
Gustav Ranis, Frances Stewart and Emma Samman
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