Results 221 to 230 of about 2,883,415 (350)

Relationships between animal welfare hazards and animal‐based welfare indicators [PDF]

open access: yesEFSA Supporting Publications, 2012
Christine Brenninkmeyer   +1 more
openaire   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

open access: yesMolecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute   +17 more
wiley   +1 more source

Integrative Multivariate Analysis of Milk Biomarkers, Productive Performance, and Animal Welfare Indicators in Dairy Cows. [PDF]

open access: yesAnimals (Basel)
Babiciu DE   +6 more
europepmc   +1 more source

Economic Globalization and the Welfare State in Affluent Democracies, 1975-1998 [PDF]

open access: yes
Prior scholarship is sharply divided on how or if globalization influences welfare states. Globalization's effects may be positive causing expansion, negative triggering crisis and reduction, curvilinear contributing to convergence, or insignificant.
Beckfield, Jason   +2 more
core  

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

open access: yesMolecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad   +35 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

The Impact of Group Size on Welfare Indicators of Ewes during Pregnancy

open access: gold, 2016
Xavier Averós   +3 more
openalex   +2 more sources

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