A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
An Integrated Approach Using Temperature-Humidity Index, Productivity, and Welfare Indicators for Herd-Level Heat Stress Assessment in Dairy Cows. [PDF]
Animals (Basel)Mylostyvyi R, Izhboldina O.
europepmc +1 more source
Influences on the assessment of resource- and animal-based welfare indicators in unweaned dairy calves for usage by farmers. [PDF]
J Anim Sci, 2021 Hayer JJ +4 more
europepmc +1 more source
How Has the Literature on Gini's Index Evolved in the Past 80 Years? [PDF]
The Gini coefficient or index is perhaps one of the most used indicators of social and economic conditions. From its first proposal in English in 1921 to the present, a large number of papers on the Gini index has been written and published.
Kuan Xu
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Tracking Epidermal Cortisol and Oxytocin in Managed Bottlenose Dolphins as Potential Non-Invasive Physiological Welfare Indicators. [PDF]
Animals (Basel)Agustí C +7 more
europepmc +1 more source
Assessment of Pupillometry Across Different Commercial Systems of Laying Hens to Validate Its Potential as an Objective Indicator of Welfare [PDF]
Elyse Mosco, David P. Kilroy, Arun Kumar
openalex +1 more source
Embedding as a pitfall for survey-based welfare indicators: Evidence from an experiment
, 2017 How can we assess the welfare of a society, its evolution over time and predict its change due to particular policy interventions? One way is to use survey-based welfare indicators such as the OECD Better Life Index. It invites people to weight a variety
Hetschko, Clemens +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Impact of feeding a high fiber diet and roughage on stress and clinical welfare indicators in fast-growing broiler breeder pullets. [PDF]
Poult SciWurtz KE, Thodberg K, Riber AB.
europepmc +1 more source