Results 71 to 80 of about 181,890 (264)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Navigating the market of welfare services: The choice of upper secondary school in Sweden

open access: yesNordic Journal of Social Research, 2014
Due to increased market orientation and deregulation, welfare services in Sweden have taken on the form of market-based services. The body of research on deregulation and privatization is quite substantial regarding the implications of this kind of ...
Torbjörn Hjort, Alexandru Panican
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Accessibility to Welfare Services and Communities: Enabling Integration and Human Rights

open access: yesSocial Inclusion
This thematic issue discusses the accessibility of welfare services and communities, emphasising its role in enabling integration and the realization of human rights.
Suvi Raitakari   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Ethical Implications of AI‐Driven Chatbots in Domestic Violence Support

open access: yesSocial Inclusion
Our study explored the opportunities, challenges, and ethical considerations of using artificial intelligence (AI)‐driven chatbots in domestic violence (DV) support. DV is a serious public health and social problem. Identifying it as early as possible is
Hanna Mielismäki, Marita Husso
doaj   +1 more source

Motivational and Ideological Underpinnings of Welfare Preferences in Eastern and Western Europe

open access: yesEurope's Journal of Psychology, 2016
In our study we investigated the motivational and ideological correlates of the approval of welfare services in postsocialist Central Eastern and Western Europe.
Márton Hadarics
doaj   +1 more source

Disability and welfare services

open access: yes, 2017
This chapter examines people’s experiences of welfare policy intended to address the rights of people with disabilities as citizens of China. It applies a conceptual framework of disability and welfare from human rights (CRPD 2008). In a rights framework, meeting people’s support needs is required to fulfil their rights as citizens.
Fisher, KR, Shang, X, Blaxland, M
openaire   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

The 2021 extreme rainfall in Gävle, Sweden: impacts on municipal welfare services and actions towards more resilient premises and operations

open access: yesHydrology Research
Climate-related risks, vulnerabilities, and impacts are increasing in cities, illustrated by precipitation-driven pluvial floods. Post-event analyses can aid in reducing urban flood risks, but knowledge gaps exist regarding how welfare services and ...
Erik Glaas   +2 more
doaj   +1 more source

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