Results 91 to 100 of about 1,242,988 (308)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Money in a theory of exchange [PDF]
Major problems in monetary economics are to: introduce money into the economy in a way that explains how money arises endogenously; explain why money is preferred to other methods of exchange; and identify the welfare gains from using money.
Daniel L. Thornton
core
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
The Welfare State: A General Theory [PDF]
, 2000 A major orginal work of social theory, this book presents a distinctive and tightly argued theoretical model for understanding the basis of welfare in society. The author develops a theory of welfare based on a series of basic propositions: that people live in society and have obligations to each other; that welfare is obtained and maintained through ...
openaire +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Changing the culture of the welfare office: the role of intermediaries in linking TANF recipients with jobs - commentary [PDF]
Welfare ; Employment (Economic theory ...
Kathryn Edin, Rebecca Joyce Kissane
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Health Adjusted GDP (HAGDP) Measures of the Relationship Between Economic Growth, Health Outcomes and Social Welfare [PDF]
Welfare economic analysis of health issues and policies can provide well balanced orderings of the state of the economy. This paper provides an innovative framework for welfare economic analysis of the relationships between economic growth, health ...
Matthew Clarke, Sardar M. N. Islam
core
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Mammaforum som politisk debattarena - En analyse av nettdebatt om velferdsstaten
Norsk Medietidsskrift, 2015 Motherhood forums as arenas for political debate – An analysis of online discussions about the welfare state. This article analyses online debate in a popular Norwegian discussion forum for mothers, a forum in which participants discuss a wide range of
Brita Ytre-Arne
doaj