Results 81 to 90 of about 27,143,692 (378)

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Children's subjective well-being : International comparative perspectives [PDF]

, 2011
We are enjoined by the United Nations Convention on the Rights of the Child to take account of the views of children. One way this can be done is by asking children about their lives in sample surveys.
Bradshaw, Jonathan, Goswami, Haridhan, Keung, Antonia, Rees, Gwyther   +3 more
core   +1 more source

Competition and Well-Being [PDF]

This paper experimentally studies the effects of competition in an environment where people’s actions can not be contractually fixed. We find that, in comparison with no competition, the presence of competition does neither increase efficiency nor does ...
Brandts,Jordi, Riedl,Arno, Winden,Frans,van   +2 more
core   +4 more sources

Study of body composition and motor competence in children from the 1st basic cycle and their relationship with school performance

BMC Pediatrics
Childhood obesity is a public health problem that affects many parts of the world, and is one of the factors that has negatively influenced levels of motor competence at an early age. However, these relationships remain poorly investigated.
Miguel Rebelo, Samuel Honório, António Pais, Jorge Santos, Paulo Afonso, Catarina Marques, Afonso Diniz, João Serrano   +7 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Fostering global well-being [PDF]

As the world prepares for the new millennium, all countries are trying quickly to adjust to changing needs within the increasingly mobile global marketplace.
Bathrick, David D.
core   +1 more source

Antimicrobial potential of Hippocratea Indica Willd. Acetone Leaf fractions against Salmonella Typhi: an in vitro and in silico study

Scientific Reports
Salmonella Typhi is a major global concern in many low- and middle-income countries. In addition, the emergence and persistence of drug resistant strains has increased the impact of this disease.
Akinyomade Oladipo Owolabi, Oghenerobor Benjamin Akpor, James Ajigasokoa Ndako, Stephen Oluwagbemiga Owa, Abimbola Peter Oluyori, Emmanuel Olorunleke Oludipe, Samson Olusegun Afolabi, Rotdelmwa Maimako Asaleye   +7 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Better mental health and well-being [PDF]

, 2014
Mental ill-health imposes a huge burden on individuals, their families, society, health systems and the economy. Mental health care remains a neglected area of health policy in too many countries.
Cachia, John M.
core  

Nrf2 induction potency of plant-derived compounds determined using an antioxidant response element luciferase reporter and conventional NAD(P)H-quinone acceptor oxidoreductase 1 activity assay

BMC Research Notes
Objective Various plants have been reported to contain compounds that promote the transcriptional activity of Nuclear factor erythroid 2-related factor 2 (Nrf2) to induce a set of xenobiotic detoxifying enzymes, such as NAD(P)H-quinone acceptor ...
Erina Tamaru, Daichi Kokubu, Yusuke Ushida, Ken Itoh   +3 more
doaj   +1 more source