Results 21 to 30 of about 706,792 (210)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

On Reflection Orders Compatible with a Coxeter Element [PDF]

open access: yes, 2015
In this article we give a simple, almost uniform proof that the lattice of noncrossing partitions associated with a well-generated complex reflection group is lexicographically shellable. So far a uniform proof is available only for Coxeter groups.
Mühle, Henri
core  

VOAs labelled by complex reflection groups and 4d SCFTs [PDF]

open access: yes, 2019
We define and study a class of $\mathcal{N}=2$ vertex operator algebras $\mathcal{W}_{\mathcal{\mathsf{G}}}$ labelled by complex reflection groups. They are extensions of the $\mathcal{N}=2$ super Virasoro algebra obtained by introducing additional ...
Bonetti, Federico   +2 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A new non-arithmetic lattice in PU(3,1)

open access: yes, 2019
We study the arithmeticity of the Couwenberg-Heckman-Looijenga lattices in PU(n,1), and show that they contain a non-arithmetic lattice in PU(3,1) which is not commensurable to the non-arithmetic Deligne-Mostow lattice in PU(3,1)
Deraux, Martin
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Classification of finite groups generated by reflections and rotations

open access: yes, 2015
We survey the existing parts of a classification of finite groups generated by orthogonal transformations in a finite-dimensional Euclidean space whose fixed point subspace has codimension one or two and extend it to a complete classification.
Lange, Christian, Mikhailova, Marina A.
core   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

open access: yesFEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

On Proper Polynomial Maps of $\mathbb{C}^2.$ [PDF]

open access: yes, 2009
Two proper polynomial maps $f_1, f_2 \colon \mathbb{C}^2 \longrightarrow \mathbb{C}^2$ are said to be \emph{equivalent} if there exist $\Phi_1, \Phi_2 \in \textrm{Aut}(\mathbb{C}^2)$ such that $f_2=\Phi_2 \circ f_1 \circ \Phi_1$.
A. Dimca   +17 more
core   +2 more sources

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