Results 91 to 100 of about 828,080 (265)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Optimization Design Method for Multistage Completion String of Shunnan Ultra-Deep Horizontal Well
Shiyou jixie, 2019 To address the problem of ultra-high pressure ultra-high temperature and difficult completion string design in the ultra-deep horizontal wells in Shunnan in the north slope of Tazhong, a set of optimization design methods for ultra-deep horizontal well ...
He Tong +4 more
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Distributed Temperature Sensing Monitoring of Well Completion Processes in a CO₂ Geological Storage Demonstration Site. [PDF]
Sensors (Basel), 2018 Lee DS, Park KG, Lee C, Choi SJ.
europepmc +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Drilling and Expandable Casing Completion for Complex Formation Isolation in Sidetrack Well
Shiyou jixie, 2015 To avoid the water formation in old wells in Tahe Oilfield,the sidetrack point of old wells have to be moved upward,resulting in plugged hole by collapsed mudstone from overlying mudstone formation of Carboniferous Bachu group or Ordovician Sangtamu ...
Chen Peiliang +4 more
doaj
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Downhole Hydraulic Operated Multistage Flow Control Valve for Intelligent Well Completion System
Shiyou jixie, 2016 Downhole flow control valve is the core tool of intelligent well to realize intelligent production. The structure and working principle of downhole hydraulic operated multistage flow control valve applied in hydraulic-control fiber-monitor intelligent ...
Liao Chenglong +6 more
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