Results 91 to 100 of about 14,355,851 (187)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Optimization of Jiyang depression block X shale condensate reservoir well spacing based on geology–engineering integration

Natural Gas Industry B
Appropriate well spacing is crucial for the efficient development of shale reservoirs, as it is closely related to the degree of resource utilization. Well spacing design is influenced by both fracturing processes and geological characteristics.
Xianchao Chen, Yang Xiao, Pengyu Jiang, Hantao Xia, Hao Fan, Taotao Lei   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Well-Being or Well-Appearing? A Multi-case Analysis of Employees' Perceptions of Organizational Well-being Initiatives

, 2017
The aim of this study is to investigate the relationship between well-being initiatives and employees’ perceptions of well-being initiatives in different organizational contexts.
Massimo Pilati, Paula Ungureanu, Fabiola Bertolotti   +2 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Interference Aspects of Adaptive Modems over Slow Rayleigh Fading Channels

, 1999
Adaptive modulation can achieve channel capacity gains by adapting the number of bits per transmission symbol on a burst-by-burst basis, in harmony with channel quality fluctuations. This is demonstrated in the paper for target bit error rates of 1 and 0.
J.M. Torrance, T. Keller, Torrance, J.M., L. Hanzo, Keller, T., Hanzo, L.   +5 more
core   +1 more source

Research on the Fixation Strength of High-Temperature Geothermal Drilling Cone Bit Teeth

Energies
During the drilling process of high-temperature geothermal wells, the high temperature at the bottom of the well and the complex lithology of the formation lead to poor tooth loss prevention in cone drill bits.
Yan Yang, Dongdong Song, Lian Chen, Yingxin Yang, Haitao Ren, Shunzuo Qiu, Zequan Huang   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Fracturing interference behavior and mechanism of deep coalbed methane horizontal wells in the Daning-Jixian Block

Meitan kexue jishu
In order to accurately understand the effects of fracturing interference on deep CBM horizontal wells, 18 groups of fracturing interference events and their effects on 18 disturbed wells and 13 interfering wells in Daning-Jixian block were systematically
Haiyan CHAO, Ze LI, Huaibin ZHEN, Lele GUO, Hui ZHANG   +4 more
doaj   +1 more source