Results 51 to 60 of about 3,713,734 (286)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

DISCRIMINACIÓN DE GAS COMERCIAL Y GAS FIZZ MEDIANTE ANÁLISIS DE ATRIBUTOS AVO Y MODELADO DE SUBSTITUCIÓN DE FLUIDOS

Revista Fuentes El Reventón Energético, 2019
The Analysis of the AVO attributes based on geophysics models, rock physics and seismic modeling, has become an important tool in the study of the exploration projects, helping to recognize zones with possible commercial interest.
Andres Eduardo Calle Ochoa, César Augusto Pineda Gómez, Lorena Giraldo   +2 more
doaj  

Geomechanical brittleness index prediction for the Marcellus shale exploiting well-log attributes

Results in Engineering, 2023
Geomechanical brittleness of tight formations calculated from Poisson's Ratio with Young's Modulus requires laboratory testing of cores and/or estimation from shear wave acoustic logs.
David A. Wood
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Lithofacies Prediction from Well Log Data Based on Deep Learning: A Case Study from Southern Sichuan, China

Applied Sciences
This paper utilizes prevalent deep learning techniques, such as Convolutional Neural Networks (CNNs) and Residual Neural Networks (ResNets), along with the well-established machine learning technique, Random Forest, to efficiently distinguish between ...
Yu Shi, Junqiao Liao, Lu Gan, Rongjiang Tang   +3 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Electro-facies classification based on core and well-log data

Journal of Petroleum Exploration and Production Technology, 2023
Facies studies represent a key element of reservoir characterization. In practice, this can be done by making use of core and petrophysical data. The high cost and difficulties of drilling and coring operations coupled with the time-intensive nature of ...
Reda Al Hasan, Mohammad Hossein Saberi, Mohammad Ali Riahi, Abbas Khaksar Manshad   +3 more
doaj   +1 more source

Passive Way of Measuring QOL/Well-Being Levels Using Smartphone Log

Frontiers in Digital Health, 2022
Research on mental health states involves paying increasing attention to changes in daily life. Researchers have attempted to understand such daily changes by relying on self-reporting through frequent assessment using devices (smartphones); however ...
Wenhao Yao, Kohei Kaminishi, Naoki Yamamoto, Takashi Hamatani, Yuki Yamada, Takahiro Kawada, Satoshi Hiyama, Tsukasa Okimura, Yuri Terasawa, Takaki Maeda, Masaru Mimura, Jun Ota   +11 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Well Log Editing and Pseudo Well Log Generation Workflow

Proceedings, 2011
Well log data are essential input for petrophysical analysis, fluid substitution, AVO modeling, synthetic seismogram to surface seismic tie, seismic inversion, seismic data processing, rock physics, reservoir characterization, 4D modeling, pore pressure prediction, rock mechanic,….etc.
openaire   +2 more sources