Results 51 to 60 of about 3,726,768 (285)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Revista Fuentes El Reventón Energético, 2019 The Analysis of the AVO attributes based on geophysics models, rock physics and seismic modeling, has become an important tool in the study of the exploration projects, helping to recognize zones with possible commercial interest.
Andres Eduardo Calle Ochoa +2 more
doaj
Iraqi Geological Journal, 2023 Machine learning has a significant advantage for many difficulties in the oil and gas industry, especially when it comes to resolving complex challenges in reservoir characterization.
Usama Alameedy, Ahmed Almomen, Najah Abd
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Applied SciencesThis paper utilizes prevalent deep learning techniques, such as Convolutional Neural Networks (CNNs) and Residual Neural Networks (ResNets), along with the well-established machine learning technique, Random Forest, to efficiently distinguish between ...
Yu Shi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Geomechanical brittleness index prediction for the Marcellus shale exploiting well-log attributes
Results in Engineering, 2023 Geomechanical brittleness of tight formations calculated from Poisson's Ratio with Young's Modulus requires laboratory testing of cores and/or estimation from shear wave acoustic logs.
David A. Wood
doaj +1 more source
Well Log Editing and Pseudo Well Log Generation Workflow
Proceedings, 2011 Well log data are essential input for petrophysical analysis, fluid substitution, AVO modeling, synthetic seismogram to surface seismic tie, seismic inversion, seismic data processing, rock physics, reservoir characterization, 4D modeling, pore pressure prediction, rock mechanic,….etc.
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source