LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Bidirectional Gated Recurrent Unit Network Based on the Inception Module (Inception-BiGRU) Predicts the Missing Data by Well Logging Data. [PDF]
ACS Omega, 2023 Sun Y, Zhang J, Yu Z, Zhang Y, Liu Z.
europepmc +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Application of well logging technology in geothermal resource evaluation: A case study of geothermal water wells in the Qianjiang sag, Jianghan Basin. [PDF]
Sci Prog, 2023 Shi W +8 more
europepmc +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Bidirectional Long Short-term Neural Network Based on the Attention Mechanism of the Residual Neural Network (ResNet-BiLSTM-Attention) Predicts Porosity through Well Logging Parameters. [PDF]
ACS Omega, 2023 Sun Y, Zhang J, Yu Z, Zhang Y, Liu Z.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Research on water content measurement method based on heat transfer method
HeliyonDuring the measurement of multiphase flow in low yield oil wells, the liquid volume will vary with the operating characteristics of the pumping unit.
Hongwei Qin +3 more
doaj +1 more source
Gathering a corpus of multimodal computer-mediated meetings with focus on text and audio interaction [PDF]
, 2006 In this paper we describe the gathering of a corpus of synchronised speech and text interaction over the network. The data collection scenarios characterise audio meetings with a significant textual component.
Bouamrane, Matt-Mouley +2 more
core +1 more source