Results 71 to 80 of about 355,630 (305)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Виділення порід-колекторів підвищеної електропровідності за даними ГДС (на прикладі неогенових відкладів Гуцулівського газового родовища) [PDF]

, 2011
Розглядається проблема виділення порід-колекторів підвищеної електропровідності за даними геофізичних досліджень свердловин (ГДС). Наведено фактичні результати визначення гранулометричного складу порід, виконано комплексну інтерпретацію даних ГДС ...
Трубенко, О. М., Федоришин, С. Д., Федорів, В. В.   +2 more
core  

Rainfall but not selective logging affect changes in abundance of tropical forest butterfly in Sabah, Borneo [PDF]

, 2003
We investigated the effects of rainfall on the distribution and abundance of the satyrine butterfly Ragadia makuta in selectively logged and unlogged forest on Borneo. In 1997-98, there was a severe El Nino-Southern Oscillation (ENSO) drought, and annual
Chey, V K, Dawood, M M, Hamer, K C, Hill, J K, Tangah, J   +4 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Selection criteria and feasibility of the inversion model for azimuthal electromagnetic logging while drilling (LWD)

Petroleum Exploration and Development, 2018
Azimuthal electromagnetic logging while drilling (LWD), which is capable of providing accurate position information approaching bed boundary, has been widely applied in real-time geosteering.
Lei WANG, Yiren FAN, Chao YUAN, Zhenguan WU, Shaogui DENG, Weina ZHAO   +5 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Downhole logging as a paeoceanographic tool on ocean drilling program leg 138: Interface between high-resolution stratigraphy and regional syntheses [PDF]

, 1992
On Ocean Drilling Program (ODP) Leg 138, standard shipboard procedures were modified to allow for the real-time monitoring of several laboratory core-scanning systems that provide centimeter-scale measurements of saturated bulk density, magnetic ...
Bloomer, Stephen F., Dadey, Kathleen A., Hagelberg, T. K., Lyle, Mitchell, Mayer, Larry A., Pisias, Nicklas G., Shipboard Scientific Party   +6 more
core   +4 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A novel productivity evaluation approach based on the morphological analysis and fuzzy mathematics: insights from the tight sandstone gas reservoir in the Ordos Basin, China

Journal of Petroleum Exploration and Production Technology, 2019
Tight gas reservoirs have rich potential resources, which are hot spots in unconventional oil and gas exploration and development. Due to their strong heterogeneity and complex pore structures, the conventional approaches of productivity evaluation ...
Shanyong Liu, Gongyang Chen, Yishan Lou, Liang Zhu, Daoyao Ge   +4 more
doaj   +1 more source