Results 41 to 50 of about 537,823 (304)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Healthy ageing in place: perspectives on age-friendliness in ‘local’ communities

BMC Public Health
Background Age-friendly communities are designed to support older adults in staying healthy, active, and engaged in society as they age. While the built environment plays an important role in their wellbeing, little is known about what shapes older ...
Ragy Tadrous, Victoria J. Palmer, Jonathan R. Olsen, Martin Anderson, Benjamin P. Rigby, Meigan Thomson, Ruth Lewis, Kirstin Mitchell, Emily Long, Kathryn Skivington, Sharon A. Simpson   +10 more
doaj   +1 more source

The challenge of defining wellbeing [PDF]

, 2012
Wellbeing is a growing area of research, yet the question of how it should be defined remains unanswered. This multi-disciplinary review explores past attempts to define wellbeing and provides an overview of the main theoretical perspectives, from the ...
Dodge, Rachel, Huyton, Jan, Daly, Annette P., Sanders, Lalage D.   +3 more
core   +2 more sources

Gravity‐Dependent Modulation of Downbeat Nystagmus: Insights From Velocity‐Storage Dysfunction

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Downbeat nystagmus varies with head position, a phenomenon termed gravity‐dependent modulation. We aimed to clarify its mechanism using a velocity‐storage model. Methods In 10 patients with downbeat nystagmus due to cerebellar disorders, we recorded eye movements at different pitch‐ and roll‐axis head positions.
Ji‐Hyung Park, Eun‐Hyuk Choi, Jorge Otero‐Millan, David S. Zee, Jeong‐Yoon Choi, Ji‐Soo Kim   +5 more
wiley   +1 more source

Wellbeing in Bhutan [PDF]

, 2015
Gross National Happiness (GNH) is often recommended as a new approach to assessing economic and social development, and the small nation of Bhutan has become known for advocating this measure of quality of life.
Diener, Ed, Lyubchik, Nadezhda, Biswas-Diener, Robert   +2 more
core   +1 more source

Perceived Physical Activity Levels and Objective Measures: A Mixed-Methods Study of Residents Aged 65 and Above in Assisted Living Homes in Australia

Journal of Aging Research
Conclusion: This study provides valuable insight into the demographic and health factors contributing to higher levels of activity, and the perceptions of activity among older adults vulnerable to health conditions associated with inactivity.
Samaher Alowaydhah, Ishanka Weerasekara, Sarah Walmsley, Sally Keir, Jodie Marquez   +4 more
doaj   +1 more source

Structuring Wellbeing*

Philosophy and Phenomenological Research, 2021
AbstractMany questions about wellbeing involve metaphysical dependence. Does wellbeing depend on minds? Is wellbeing determined by distinct sorts of things? Is it determined differently for different subjects? However, we should distinguish two axes of dependence. First, there are thegroundsthat generate value.
openaire   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

The acceptability of a novel seismocardiography device for measuring VO2 max in a workplace setting: a mixed methods approach

BMC Public Health
Background Workplace health screening rarely includes measures of cardiorespiratory fitness, despite it being a greater predictor of cardiovascular disease and all-cause mortality than other routinely measured risk factors.
Anouska M Carter, Liam Humphreys, Alison Beswick, Sue Kesterton, Alex Bugg, Katharine Platts   +5 more
doaj   +1 more source