Results 141 to 150 of about 448,205 (292)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Culture Counts: How Five Community-Based Organizations Serve Asian and Pacific Islander Youth [PDF]
, 2003 This two-year effort to examine cultural competence involved an extensive literature review, a survey of organizations, and in-depth reviews of five community-based organizations: Asian American Recovery Services (Santa Clara office), East Bay Asian ...
Isami Arifuku +3 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2013 Předmětem diplomové práce je architektonická studie wellness centra s tématikou římských lázní a saunového světa. Wellness centrum je součástí aquaparku „Vodní svět“, umístěného u Brněnské přehrady, oblast Rakovec.
Horbalová, Lenka
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Nursing Procedures for the Patient Submitted to Cardiac Catheterism - Scientific Production Analysis
Online Brazilian Journal of Nursing, 2006 Facing the importance of existing parameters for the nursing care systematization to the patients submitted to cardiac catheterism, the necessity of availability of scientific studies related to the subject is clear in order to present the establishment ...
Rosane Brinques Lourenci
doaj
Care Works: Come Home for Care [PDF]
, 2017 Essential to executing the mission and vision of an academic medical center (AMC) is attracting and retaining the highest quality employees. As demonstrated by VCU’s commitment to the Great Place Initiative, the University has recognized that employees ...
at Virginia Commonwealth University, The Grace E. Harris Leadership Institute +6 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source