Results 191 to 200 of about 453,120 (310)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Embedding Wellness Planning in Dental Curricula: A Strategy for Impact. [PDF]

Int Dent J
Botelho M, Chan CCK.
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Development of a survey and worry score to evaluate physician burnout and wellness interventions during COVID-19 in the Rio Grande Valley: A pilot study. [PDF]

PLoS One
Jacobsen V, Vazquez EA, Herrera L, Escalera R, Salinas D, Gadad BS, Lopez-Alvarenga JC, Potter-Baker K.   +7 more
europepmc   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

trnL Metabarcoding - A Molecular Tool to Evaluate Plant Intake and Its Association With Gut Microbiome and Plasma Metabolome

Current Developments in Nutrition
Nubia Andrea Villota Salazar, Oscar J Lara-Guzmán, Vanessa Corrales-Agudelo, O Lucía Ortega-Sierra, Diego A Rivera, Jelver A Sierra, Katalina Muñoz-Durango, Juan S Escobar   +7 more
doaj   +1 more source

Enhancing referrals and utilization of the Healthy Lifestyle clinic: a pre-and post intervention study in primary health care. [PDF]

BMC Health Serv Res
Musa S, Abdeen S, Kehyayan V.
europepmc   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Regenerative and Wellness Medicine: A Boon or Barrier to Surgical Innovation in Degenerative Spine Care? [PDF]

Int J Spine Surg
Dowling Á, Lewandrowski KU, Lorio MP, Alves ÓL, Fiorelli RKA, Schmidt SL, Yuan HA, Vaccaro AR.   +7 more
europepmc   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source