Results 181 to 190 of about 983,554 (294)

Study on the construction of a model for particle size distribution of coal fines in the full wellbore of coalbed methane wells. [PDF]

Sci Rep
Kong P, Zhou M, Yao D, Fan Z, Zhang Z, Hu H, Yu W, Zhang X, Zou Q.   +8 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

LncRNA Airn preserves cardiomyocyte fatty acid oxidation to ameliorate diabetic cardiomyopathy by modulating the QKI-PPARα axis. [PDF]

Redox Biol
Peng T, Liu M, Yu Z, Wang X, Zhang Y, Wang D, Qi B, Ma W, Ma F, Song L, Hu J, Li Y.   +11 more
europepmc   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Cell Painting in activated cells illuminates phenotypic dark space and drug mechanisms of action. [PDF]

Nat Commun
Zietek MA, Lohith A, Terciano D, Rabbitts BM, Khadilkar A, MacMillan JB, Scott Lokey R.   +6 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Cellular basis for blade splitting in bull kelp, Nereocystis luetkeana. [PDF]

Am J Bot
Breitkreutz AK, Martone PT.
europepmc   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

<i>Hex</i>-MASP for mapping the whole-tissue spatial proteome and the intrabrain distribution of monoclonal antibodies. [PDF]

Proc Natl Acad Sci U S A
Huo S, Ma M, Qian S, Zhang M, Pu J, Zhu X, Rasam S, Barone T, Plunkett R, Zhou C, Qu J.   +10 more
europepmc   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source