Results 231 to 240 of about 983,554 (294)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

An accessible and open-source workflow for fabrication of custom PDMS culture chambers using 3D printing. [PDF]

MethodsX
Algarín A, Cabrera PL, Scagliusi SF, Daza P, Yúfera A, Martín D.   +5 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Seasonal assessment of groundwater quality and irrigation suitability using a solar-powered AgNP/activated carbon treatment system in a coastal aquifer. [PDF]

Sci Rep
Omar MY, Ibrahim RA, Bestawy EE, Tonbol KM, Ahmed RA.   +4 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

All-trans retinoic acid suppresses CD8⁺ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma. [PDF]

Signal Transduct Target Ther
Kang I, Kim Y, Kang BH, Kim HJ, Kim E, Kim CW, Kim HC, Park SH, Park WH, Im SH, Kim NE, Chang S, La J, Hwang I, Kim M, Ahn S, Lee SK, Chang JB, Lee HK.   +18 more
europepmc   +1 more source

S-Nitrosothiols modulate Porphyromonas gingivalis virulence. [PDF]

Redox Biol
Ramrattan TD, Stair ER, Dandu S, Morgan RL, Kumar R, Snyder QK, Hicks LM, Freeman R, Schoenfisch MH.   +8 more
europepmc   +1 more source

An A549 Cell-Based Approach Using Repeated Fluorescence Readouts for Assessing Reactive Oxygen Species Activity of Atmospheric Particulate Matter. [PDF]

Toxics
Tzagkaroulaki I, Diapouli E, Vasilatou V, Papagiannis S, Tagaris E.   +4 more
europepmc   +1 more source

Machine Learning-Driven Automated Culture Reveals Similar Performance of mTeSR+ and StemFlex in Human iP11N Pluripotent Stem Cells. [PDF]

Cells
Bogoniewski AA, Gonzalez MF, Reyes RE, Rivera SF, Taylor C, Schurr T, Damoiseaux R, Lipshutz GS.   +7 more
europepmc   +1 more source

SNRS Member Perspectives: Assessing Satisfaction, Preferences, and Needs. [PDF]

Res Nurs Health
Wells C, Akintomide M, Gengo R, Story L, Pugh V, Davis SL.   +5 more
europepmc   +1 more source