Results 161 to 170 of about 106,969 (295)

Global Climate Change and Built Heritage

Built Heritage
Lui Tam, Christopher J. Whitman, Oriel Prizeman   +2 more
doaj   +1 more source

Risk assessment for vaccination programmes in a pandemic. A Swedish model for efficacy and safety during COVID-19. [PDF]

Ups J Med Sci
Wikstöm G, Welsh M.
europepmc   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial (Baby-OSCAR trial).

Health Technol Assess
Gupta S, Subhedar NV, Bell JL, Bowler U, Clarke C, Cole C, Dempster K, Edwards C, Field D, Greenaway J, Hutchison E, Jamieson N, Johnson S, Kelsell W, Kennedy A, King A, Laube M, Linsell L, Murray D, O'Connor H, Okeke Ogwulu C, Pepperell J, Roberts T, Roehr C, Sinha S, Stanbury K, Sutton J, Welsh R, Wiles J, Wyllie J, Juszczak E, Hardy P, Baby-OSCAR Collaborative Group.   +32 more
europepmc   +1 more source

Developing the People's Experience Survey (PES): a mixed-methods study updating a patient-reported experience measure (PREM) for use in any healthcare setting across Wales. [PDF]

BMJ Open
Withers K, Palmer R, Waddington H, South K, Lewis J, Desir R.   +5 more
europepmc   +1 more source

Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis.

Cell, 1993
M. Welsh, Alan E. Smith
semanticscholar   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

Interleukin-36 upregulates type-I interferon responses in systemic lupus erythematosus by promoting the accumulation of self-nucleic acids. [PDF]

Front Immunol
Welsh EJ, McCluskey D, Baum P, Lewis MJ, Capon F.   +4 more
europepmc   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source